Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 14/20 | 0.62 |
| ▸ | PDE4A | P27815 | 7/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693277 | 0.89 | TNF (0.77) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10926667 | 0.79 | TNF (0.71) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6693021 | 0.79 | TNF (0.70) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28722625 | 0.79 | TNF (0.72) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6692623 | 0.79 | TNF (0.72) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6693845 | 0.78 | TNF (0.79) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7799770 | 0.78 | TNF (0.60) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6688763 | 0.77 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6693859 | 0.77 | TNF (0.69) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5519999 | 0.76 | KMT2A (0.62) | KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200987-B1 | ADMINISTERING AS TUMOR NECROSIS FACTOR INHIBITORS; CACHEXIA, ENDOTOXIN SHOCK; RETROVIRUS VIRICIDES | CELGENE CORPORATION | 2001-03-13 | — | — | US | disclosed |