SCHEMBL7750355

SCHEMBL7750355

COc1cc(C=NNC(=N)N)c(Cl)c(OC)c1OC

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.51
PARP2 Q9UGN5 1/20 0.51
MAPT P10636 2/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
HPGD P15428 2/20 0.46
KDM4E B2RXH2 6/20 0.45
ALDH1A1 P00352 1/20 0.45
GAA P10253 1/20 0.45
HTT P42858 4/20 0.41
POLB P06746 1/20 0.41
LMNA P02545 4/20 0.40
NPSR1 Q6W5P4 2/20 0.39
PTBP1 P26599 1/20 0.39
RECQL P46063 1/20 0.39
ALOX12 P18054 1/20 0.39
KMT2A Q03164 3/20 0.39
MEN1 O00255 1/20 0.39
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7750348 1.00 PARP1 (0.51) PARP1PARP2MAPTSMN1; SMN2HPGD
SCHEMBL5574472 0.85 PARP1 (0.47) PARP1PARP2MAPTSMN1; SMN2HPGD
SCHEMBL5574476 0.85 PARP1 (0.47) PARP1PARP2MAPTSMN1; SMN2HPGD
SCHEMBL5574481 0.85 PARP1 (0.50) PARP1PARP2MAPTSMN1; SMN2HPGD
SCHEMBL7743153 0.84 PARP1 (0.64) PARP1PARP2MAPTSMN1; SMN2HPGD
SCHEMBL529833 0.84 MAPT (0.55) PARP1PARP2MAPTHPGDKDM4E
SCHEMBL16993672 0.84 KDM4E (0.57) PARP1PARP2MAPTSMN1; SMN2HPGD
SCHEMBL530029 0.84 MAPT (0.55) PARP1PARP2MAPTHPGDKDM4E
SCHEMBL16993673 0.84 KDM4E (0.57) PARP1PARP2MAPTSMN1; SMN2HPGD
SCHEMBL7743155 0.84 PARP1 (0.64) PARP1PARP2MAPTSMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001025192-A1 GUANIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF A MEDICAMENT FOR BLOCKING XANTHINE OXIDASE/DEHYDROGENASE MELACURE THERAPEUTICS AB (SE) 2001-04-12 WO disclosed