Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7753473 | 0.82 | CDK2 (0.45) | CDK2CCNA2MAPTCDK5CDK5R1 | |
| SCHEMBL1248421 | 0.76 | CCNA2 (0.49) | CDK2CCNA2MAPTCDK5CDK5R1 | |
| SCHEMBL1250520 | 0.75 | MAPT (0.45) | CDK2CCNA2MAPTCDK5CDK5R1 | |
| SCHEMBL7756995 | 0.73 | MAPT (0.68) | CDK2CCNA2MAPTCDK5CDK5R1 | |
| SCHEMBL1250757 | 0.72 | MAPT (0.52) | CDK2CCNA2MAPTCDK5CDK5R1 | |
| SCHEMBL1249747 | 0.72 | MAPT (0.46) | CDK2CCNA2MAPTCDK5CDK5R1 | |
| SCHEMBL27609556 | 0.72 | CCNA2 (0.59) | CDK2CCNA2MAPTCDK5CDK5R1 | |
| SCHEMBL1248135 | 0.72 | MAPT (0.45) | CDK2CCNA2MAPTCDK5CDK5R1 | |
| SCHEMBL1248186 | 0.71 | MAPT (0.45) | CDK2CCNA2MAPTCDK5CDK5R1 | |
| SCHEMBL1250063 | 0.71 | MAPT (0.44) | CDK2CCNA2MAPTCDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001056567-A1 | 2,4-DIAMINOTHIAZOLE DERIVATIVES AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 (GSK-3) INHIBITORS | NOVO NORDISK A/S (DK) | 2001-08-09 | — | — | WO | disclosed |