Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.53 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PDE1A | P54750 | 1/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.52 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.49 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.49 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.49 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.49 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.49 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.49 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.49 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.49 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971544 | 1.00 | PDE5A (0.69) | PDE5APOLBSOAT2SOAT1GAA | |
| SCHEMBL7961319 | 1.00 | PDE5A (0.69) | PDE5APOLBSOAT2SOAT1GAA | |
| SCHEMBL7971549 | 1.00 | PDE5A (0.69) | PDE5APOLBSOAT2SOAT1GAA | |
| SCHEMBL7753510 | 1.00 | PDE5A (0.69) | PDE5APOLBSOAT2SOAT1GAA | |
| SCHEMBL7757262 | 1.00 | PDE5A (0.69) | PDE5APOLBSOAT2SOAT1GAA | |
| SCHEMBL7974926 | 1.00 | PDE5A (0.69) | PDE5APOLBSOAT2SOAT1GAA | |
| SCHEMBL7961322 | 1.00 | PDE5A (0.69) | PDE5APOLBSOAT2SOAT1GAA | |
| SCHEMBL7753534 | 1.00 | PDE5A (0.69) | PDE5APOLBSOAT2SOAT1GAA | |
| SCHEMBL7759510 | 1.00 | PDE5A (0.69) | PDE5APOLBSOAT2SOAT1GAA | |
| SCHEMBL8926366 | 0.98 | PDE5A (0.67) | PDE5APOLBSOAT2SOAT1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281234-B1 | TREATING METABOLIC DISORDERS MEDIATED BY INSULIN RESISTANCE OR HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION | 2001-08-28 | — | — | US | claimed |
| EP-1077960-A1 | (2-ACYLAMINOTHIAZOLE-4-YL)ACETIC ACID DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | claimed |
| WO-1999058514-A1 | (2-ACYLAMINOTHIAZOLE-4-YL)ACETIC ACID DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-18 | — | — | WO | claimed |
| US-5688821-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS, SKIN DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-18 | — | — | US | claimed |
| US-6281234-B1 | TREATING METABOLIC DISORDERS MEDIATED BY INSULIN RESISTANCE OR HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION | 2001-08-28 | — | — | US | disclosed |
| EP-1077960-A1 | (2-ACYLAMINOTHIAZOLE-4-YL)ACETIC ACID DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058514-A1 | (2-ACYLAMINOTHIAZOLE-4-YL)ACETIC ACID DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-18 | — | — | WO | disclosed |
| US-5688821-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS, SKIN DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |