Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5143830 | 1.00 | PRMT5 (0.44) | PRMT5WDR77POLBLMNAMAPK14 | |
| SCHEMBL5146439 | 0.89 | PRMT5 (0.48) | PRMT5WDR77POLBMAPK14MEN1 | |
| SCHEMBL5143786 | 0.88 | PRMT5 (0.46) | PRMT5WDR77POLBLMNAMAPK14 | |
| Hydrochloric Acid SCHEMBL5142011 | 0.86 | MAPK14 (0.49) | PRMT5WDR77POLBLMNAMAPK14 | |
| SCHEMBL5143801 | 0.83 | TAOK1 (0.45) | PRMT5WDR77LMNA | |
| Hydrochloric Acid SCHEMBL5141963 | 0.83 | PRMT5 (0.47) | PRMT5WDR77POLBLMNAMEN1 | |
| SCHEMBL5142063 | 0.82 | PRMT5 (0.43) | PRMT5WDR77LMNAMEN1KMT2A | |
| SCHEMBL5142064 | 0.82 | PRMT5 (0.43) | PRMT5WDR77LMNAMEN1KMT2A | |
| SCHEMBL5142058 | 0.81 | PRMT5 (0.44) | PRMT5WDR77POLBLMNAADRB3 | |
| SCHEMBL5144081 | 0.81 | PRMT5 (0.44) | PRMT5WDR77POLBLMNAADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070046-A1 | PROPANOLAMINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051564-A1 | PROPANOLAMINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-14 | — | — | WO | disclosed |