SCHEMBL7753836

SCHEMBL7753836

CCOC(C)C(=O)Oc1ccc(OCCn2c(CC)nc3ccccc3c2=O)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.46
HRH3 Q9Y5N1 2/20 0.46
ACKR3 P25106 5/20 0.46
L3MBTL1 Q9Y468 3/20 0.45
GAA P10253 2/20 0.45
PPARG P37231 1/20 0.44
PPARD Q03181 1/20 0.44
PPARA Q07869 1/20 0.44
TSHR P16473 2/20 0.44
ATM Q13315 1/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
CYP1A2 P05177 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
MAPT P10636 1/20 0.43
TDP1 Q9NUW8 2/20 0.43
LMNA P02545 1/20 0.43
ALDH1A1 P00352 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7753447 0.90 TSHR (0.48) HRH3L3MBTL1GAAPPARGPPARD
SCHEMBL6555809 0.83 PPARA (0.58) KCNH2HRH3L3MBTL1GAAPPARG
SCHEMBL6555767 0.82 PPARG (0.68) PPARGPPARDPPARA
SCHEMBL7004808 0.81 PPARG (0.67) PPARGPPARDPPARAADRA1A
SCHEMBL7006234 0.81 PPARG (0.67) PPARGPPARDPPARAADRA1A
Lithium SCHEMBL7004819 0.81 PPARG (0.67) PPARGPPARDPPARAADRA1A
SCHEMBL6555815 0.81 PPARG (0.44) KCNH2HRH3ACKR3L3MBTL1GAA
SCHEMBL7577960 0.80 ACKR3 (0.47) KCNH2HRH3ACKR3L3MBTL1GAA
SCHEMBL7006236 0.80 PPARG (0.59) PPARGPPARDPPARAMAPT
Lithium Ion SCHEMBL7004812 0.80 PPARG (0.59) PPARGPPARDPPARAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1073643-A2 NEW HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 2001-02-07 EP disclosed
WO-1999008501-A2 NEW HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 1999-02-25 WO disclosed