Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 8/20 | 0.82 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.82 |
| ▸ | AR | P10275 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7756373 | 1.00 | SRD5A1 (0.82) | SRD5A1SRD5A2AR | |
| SCHEMBL7755911 | 0.91 | SRD5A1 (0.84) | SRD5A1SRD5A2AR | |
| SCHEMBL7757861 | 0.91 | SRD5A1 (0.84) | SRD5A1SRD5A2AR | |
| SCHEMBL8894599 | 0.90 | SRD5A1 (1.00) | SRD5A1SRD5A2AR | |
| SCHEMBL8894610 | 0.90 | SRD5A1 (1.00) | SRD5A1SRD5A2AR | |
| SCHEMBL7754614 | 0.90 | SRD5A1 (0.84) | SRD5A1SRD5A2AR | |
| SCHEMBL7754606 | 0.90 | SRD5A1 (0.84) | SRD5A1SRD5A2AR | |
| SCHEMBL8823379 | 0.89 | SRD5A1 (0.79) | SRD5A1SRD5A2AR | |
| SCHEMBL8823385 | 0.89 | SRD5A1 (0.79) | SRD5A1SRD5A2AR | |
| SCHEMBL7757838 | 0.88 | SRD5A1 (0.78) | SRD5A1SRD5A2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663924-B1 | 17-BETA-CARBOXANILIDES OF 4-AZA-5-ALPHA-ANDROSTAN-3-ONES AS 5-ALPHA-REDUCTASE INHIBITORS | MERCK & CO INC (US) | 2001-02-14 | — | — | EP | claimed |
| US-5693810-A | ENZYME INHIBITORS OF TESTOSTERONE-5ALPHA-REDUCTASE TO PREVENT OR LESSEN SYMPTOMS OF DIHYDROTESTOSTERONE-RELATED HYPERANDROGENIC CONDITIONS, E.G. PROSTATE PROBLEMS, SKIN DISORDERS | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | claimed |
| EP-0663924-A4 | 17-g(b)-CARBOXANILIDES OF 4-AZA-5-g(a)-ANDROSTAN-3-ONES AS 5-g(a)-REDUCTASE INHIBITORS. | MERCK & CO INC (US) | 1995-10-04 | — | — | EP | claimed |
| EP-0663924-A1 | 17$g(b)-CARBOXANILIDES OF 4-AZA-5$g(a)-ANDROSTAN-3-ONES AS 5$g(a)-REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1995-07-26 | — | — | EP | claimed |
| WO-1994007861-A1 | 17β-CARBOXANILIDES OF 4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 1994-04-14 | — | — | WO | claimed |
| EP-0663924-B1 | 17-BETA-CARBOXANILIDES OF 4-AZA-5-ALPHA-ANDROSTAN-3-ONES AS 5-ALPHA-REDUCTASE INHIBITORS | MERCK & CO INC (US) | 2001-02-14 | — | — | EP | disclosed |
| US-5693810-A | ENZYME INHIBITORS OF TESTOSTERONE-5ALPHA-REDUCTASE TO PREVENT OR LESSEN SYMPTOMS OF DIHYDROTESTOSTERONE-RELATED HYPERANDROGENIC CONDITIONS, E.G. PROSTATE PROBLEMS, SKIN DISORDERS | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |
| EP-0663924-A4 | 17-g(b)-CARBOXANILIDES OF 4-AZA-5-g(a)-ANDROSTAN-3-ONES AS 5-g(a)-REDUCTASE INHIBITORS. | MERCK & CO INC (US) | 1995-10-04 | — | — | EP | disclosed |
| EP-0663924-A1 | 17$g(b)-CARBOXANILIDES OF 4-AZA-5$g(a)-ANDROSTAN-3-ONES AS 5$g(a)-REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1995-07-26 | — | — | EP | disclosed |
| WO-1994007861-A1 | 17β-CARBOXANILIDES OF 4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 1994-04-14 | — | — | WO | disclosed |