SCHEMBL7757286

SCHEMBL7757286

CCCCC[SiH]1CCC([C@H]2CC[C@H](COc3ccc(F)c(F)c3)CC2)CC1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 3/20 0.38
PARP15 Q460N3 2/20 0.38
FFAR4 Q5NUL3 2/20 0.35
SCN9A Q15858 2/20 0.35
BACE1 P56817 2/20 0.35
BACE2 Q9Y5Z0 2/20 0.35
TRPV4 Q9HBA0 1/20 0.34
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
HTR3A P46098 1/20 0.34
KCNH2 Q12809 1/20 0.34
CRBN Q96SW2 1/20 0.33
KDR P35968 1/20 0.33
KDM1A O60341 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7757294 1.00 PARP10 (0.38) PARP10PARP15FFAR4SCN9ABACE1
SCHEMBL7757290 1.00 PARP10 (0.38) PARP10PARP15FFAR4SCN9ABACE1
SCHEMBL7760350 0.93 PARP10 (0.41) PARP10PARP15FFAR4SCN9ASLC6A2
SCHEMBL7760352 0.93 PARP10 (0.41) PARP10PARP15FFAR4SCN9ASLC6A2
SCHEMBL7761363 0.92 PARP10 (0.40) PARP10PARP15FFAR4SCN9ASLC6A2
SCHEMBL7761368 0.92 PARP10 (0.40) PARP10PARP15FFAR4SCN9ASLC6A2
SCHEMBL7761418 0.92 PARP10 (0.40) PARP10PARP15FFAR4SCN9ABACE1
SCHEMBL7761412 0.92 PARP10 (0.40) PARP10PARP15FFAR4SCN9ABACE1
SCHEMBL7761415 0.92 PARP10 (0.40) PARP10PARP15FFAR4SCN9ABACE1
SCHEMBL7757393 0.90 PARP10 (0.39) PARP10PARP15FFAR4SCN9ABACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0714899-B1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHINETSU CHEMICAL CO (JP) 2001-04-18 EP disclosed
US-5641430-A Silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-06-24 US disclosed
EP-0714899-A1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-05 EP disclosed