SCHEMBL7757316

SCHEMBL7757316

Fc1ccc(OCC2CCC([C@H]3CC[Si@H](Cl)CC3)CC2)cc1F

nearest known ligand 0.55

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 3/20 0.43
PARP15 Q460N3 2/20 0.43
TRPV4 Q9HBA0 1/20 0.40
FFAR4 Q5NUL3 1/20 0.40
SCN9A Q15858 2/20 0.37
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
HTR3A P46098 1/20 0.36
KCNH2 Q12809 1/20 0.36
FFAR1 O14842 1/20 0.36
PPARD Q03181 1/20 0.36
PDK2 Q15119 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7757312 1.00 PARP10 (0.43) PARP10PARP15TRPV4FFAR4SCN9A
SCHEMBL7757324 1.00 PARP10 (0.43) PARP10PARP15TRPV4FFAR4SCN9A
SCHEMBL7760369 0.92 PARP10 (0.47) PARP10PARP15TRPV4FFAR4SCN9A
SCHEMBL7763787 0.90 PARP10 (0.41) PARP10PARP15TRPV4FFAR4SCN9A
SCHEMBL7763800 0.90 PARP10 (0.41) PARP10PARP15TRPV4FFAR4SCN9A
SCHEMBL7763793 0.90 PARP10 (0.41) PARP10PARP15TRPV4FFAR4SCN9A
SCHEMBL7762475 0.86 PARP10 (0.36) PARP10PARP15TRPV4FFAR4SCN9A
SCHEMBL7762470 0.86 PARP10 (0.36) PARP10PARP15TRPV4FFAR4SCN9A
SCHEMBL7762468 0.86 PARP10 (0.36) PARP10PARP15TRPV4FFAR4SCN9A
SCHEMBL14901056 0.84 PARP10 (0.55) PARP10PARP15FFAR4SCN9ASLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0714899-B1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHINETSU CHEMICAL CO (JP) 2001-04-18 EP disclosed
US-5641430-A Silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-06-24 US disclosed
EP-0714899-A1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-05 EP disclosed