Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.62 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.59 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7754154 | 0.94 | MEN1 (0.67) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL7757108 | 0.86 | OPRL1 (0.64) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL7757095 | 0.86 | OPRL1 (0.83) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL7758870 | 0.85 | MEN1 (0.66) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL7759204 | 0.84 | MEN1 (0.65) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL20187031 | 0.84 | OPRL1 (0.67) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL7992816 | 0.84 | OPRL1 (0.66) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL7759170 | 0.83 | MEN1 (0.77) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL7995842 | 0.83 | CYP2D6 (0.80) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL7982605 | 0.83 | MEN1 (0.76) | MEN1CYP3A4CYP2D6CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277991-B1 | FOR TREATMENT OF MIGRAINE, NON-INSULIN DEPENDENT DIABETES MELLITUS, SEPSIS, INFLAMMATION, INCONTINENCE, VASOMOTOR DISTURBANCES SUCH AS HOT FLUSHES OR HOT FLASHES | NOVO NORDISK A/S (DK) | 2001-08-21 | — | — | US | claimed |
| EP-1080091-A1 | NOVEL 1,3,8-TRIAZASPIRO[4.5]DECANONES WITH HIGH AFFINITY FOR OPIOID RECEPTOR SUBTYPES | Novo Nordisk A/S (DK) | 2001-03-07 | — | — | EP | claimed |
| WO-1999059997-A1 | NOVEL 1,3,8-TRIAZASPIRO[4.5]DECANONES WITH HIGH AFFINITY FOR OPIOID RECEPTOR SUBTYPES | NOVO NORDISK A/S (DK) | 1999-11-25 | — | — | WO | claimed |
| US-6277991-B1 | FOR TREATMENT OF MIGRAINE, NON-INSULIN DEPENDENT DIABETES MELLITUS, SEPSIS, INFLAMMATION, INCONTINENCE, VASOMOTOR DISTURBANCES SUCH AS HOT FLUSHES OR HOT FLASHES | NOVO NORDISK A/S (DK) | 2001-08-21 | — | — | US | disclosed |
| EP-1080091-A1 | NOVEL 1,3,8-TRIAZASPIRO[4.5]DECANONES WITH HIGH AFFINITY FOR OPIOID RECEPTOR SUBTYPES | Novo Nordisk A/S (DK) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059997-A1 | NOVEL 1,3,8-TRIAZASPIRO[4.5]DECANONES WITH HIGH AFFINITY FOR OPIOID RECEPTOR SUBTYPES | NOVO NORDISK A/S (DK) | 1999-11-25 | — | — | WO | disclosed |