SCHEMBL7759151

SCHEMBL7759151

OC[C@@H](OC1OCCN(Cc2nc[nH]n2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 18/20 0.58
TACR3 P29371 2/20 0.58
NR3C1 P04150 1/20 0.58
CYP3A4 P08684 1/20 0.58
FPR1 P21462 1/20 0.58
GPR183 P32249 1/20 0.58
OPRD1 P41143 1/20 0.58
GPR65 Q8IYL9 1/20 0.58
GPR35 Q9HC97 1/20 0.58
TACR2 P21452 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7759145 1.00 TACR1 (0.58) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL3370723 1.00 TACR1 (0.58) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL3370718 1.00 TACR1 (0.58) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL3370721 1.00 TACR1 (0.58) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL5224196 0.89 TACR1 (0.55) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL6604634 0.88 TACR1 (0.74) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL6604637 0.88 TACR1 (0.74) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL5224202 0.88 TACR1 (0.57) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL5223101 0.85 TACR1 (0.80) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL5264189 0.85 TACR1 (0.55) TACR1TACR3NR3C1CYP3A4FPR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1087771-A1 USE OF A NK-1 RECEPTOR ANTAGONIST FOR TREATING BIPOLAR DISORDERS MERCK SHARP & DOHME LTD. (GB) 2001-04-04 EP disclosed
WO-1999064007-A1 USE OF A NK-1 RECEPTOR ANTAGONIST FOR TREATING BIPOLAR DISORDERS MERCK SHARP & DOHME LIMITED (GB) 1999-12-16 WO disclosed