Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.52 |
| ▸ | PDE4A | P27815 | 6/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914451 | 1.00 | PDE4B (0.52) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7995009 | 1.00 | PDE4B (0.52) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7394762 | 0.88 | PDE4B (0.58) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7845534 | 0.86 | PDE4A (0.56) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL6587626 | 0.85 | PDE4B (0.48) | PDE4BPDE4APDE4DPDE4CPOLB | |
| Ammonia Solution, Strong SCHEMBL7995011 | 0.85 | PDE4A (0.52) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL3656868 | 0.84 | KDM4E (0.44) | — | |
| SCHEMBL7915910 | 0.84 | PDE4A (0.49) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL7906195 | 0.83 | PDE4B (0.54) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL7400479 | 0.83 | PDE4B (0.49) | PDE4BPDE4APDE4DPDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859766-B1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AG (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-6025376-A | INHIBITORS OF TUMOR NECROSIS FACTOR, TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |