⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24566372 | 0.79 | CYP19A1 (0.32) | — | |
| SCHEMBL15088114 | 0.70 | — | — | |
| SCHEMBL3933129 | 0.64 | — | — | |
| SCHEMBL3447627 | 0.59 | — | — | |
| SCHEMBL22235524 | 0.47 | — | — | |
| SCHEMBL893 | 0.43 | — | — | |
| SCHEMBL15048839 | 0.41 | TYMP (0.40) | — | |
| Hydrochloric Acid SCHEMBL11545361 | 0.39 | — | — | |
| Methane SCHEMBL15272188 | 0.39 | — | — | |
| Cyclopentene SCHEMBL9112 | 0.37 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625155-B1 | PYRROLOIMIDAZOLYL AND IMIDAZOPYRIDINYL SUBSTITUTED 1H-BENZIMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2001-08-08 | — | — | EP | claimed |
| US-5491161-A | TREATMENT OF SEX HORMONE DEPENDANT DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-02-13 | — | — | US | claimed |
| US-5457102-A | Sex hormone inhibitor, antiestrogens, aromatase inhibitor | JANSSEN PHARMACEUTICA, N.V. (BE) | 1995-10-10 | — | — | US | claimed |
| EP-0625155-A1 | PYRROLOIMIDAZOLYL AND IMIDAZOPYRIDINYL SUBSTITUTED 1H-BENZIMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-11-23 | — | — | EP | claimed |
| WO-1993015079-A1 | PYRROLOIMIDAZOLYL AND IMIDAZOPYRIDINYL SUBSTITUTED 1H-BENZIMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-08-05 | — | — | WO | claimed |
| US-5066656-A | Aromatase inhibitor, prevention of biosynthesis of estrogens, treatment of estrogen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-11-19 | — | — | US | claimed |
| JP-3153686-A | — | — | None | — | — | JP | disclosed |
| EP-0625155-B1 | PYRROLOIMIDAZOLYL AND IMIDAZOPYRIDINYL SUBSTITUTED 1H-BENZIMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2001-08-08 | — | — | EP | disclosed |
| US-5491161-A | TREATMENT OF SEX HORMONE DEPENDANT DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-02-13 | — | — | US | disclosed |
| US-5457102-A | Sex hormone inhibitor, antiestrogens, aromatase inhibitor | JANSSEN PHARMACEUTICA, N.V. (BE) | 1995-10-10 | — | — | US | disclosed |
| EP-0625155-A1 | PYRROLOIMIDAZOLYL AND IMIDAZOPYRIDINYL SUBSTITUTED 1H-BENZIMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015079-A1 | PYRROLOIMIDAZOLYL AND IMIDAZOPYRIDINYL SUBSTITUTED 1H-BENZIMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-08-05 | — | — | WO | disclosed |
| US-5066656-A | Aromatase inhibitor, prevention of biosynthesis of estrogens, treatment of estrogen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-11-19 | — | — | US | disclosed |
| US-5066656-A | Aromatase inhibitor, prevention of biosynthesis of estrogens, treatment of estrogen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-11-19 | — | — | US | disclosed |
| EP-0426225-A3 | (6,7-DIHYDRO-5H-PYRROLO(1,2-C)-IMIDAZOL-5-YL)- AND (5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL) SUBSTITUTED 1H-BENZOTRIAZOLE DERIVATIVES | — | 1991-10-09 | — | — | EP | disclosed |
| JP-H03153686-A | (6,7-DIHYDRO-5H-PYRROLO(1,2-C)IMIDAZOL-5-YL)-AND (5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL) SUBSTITUTED 1H-BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUT NV | 1991-07-01 | — | — | JP | disclosed |
| EP-0426225-A2 | (6,7-dihydro-5H-pyrrolo[1,2-c]-imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-05-08 | — | — | EP | disclosed |
| EP-0426225-A2 | (6,7-dihydro-5H-pyrrolo[1,2-c]-imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-05-08 | — | — | EP | disclosed |