⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7767651 | 1.00 | — | — | |
| SCHEMBL336815 | 0.66 | — | — | |
| SCHEMBL9978118 | 0.64 | — | — | |
| SCHEMBL15954810 | 0.63 | LRRK2 (0.38) | — | |
| SCHEMBL432910 | 0.51 | — | — | |
| SCHEMBL2489441 | 0.51 | — | — | |
| SCHEMBL10508164 | 0.51 | — | — | |
| SCHEMBL7616343 | 0.42 | — | — | |
| Formamide SCHEMBL11470893 | 0.42 | TYMP (0.33) | — | |
| Pyrazine SCHEMBL445420 | 0.40 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653422-B1 | Process for the preparation of 2-substituted 5-chlorimidazole-4-carbaldehydes | LONZA AG (CH) | 1998-02-25 | — | — | EP | claimed |
| US-5536841-A | Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes | LONZA LTD. (CH) | 1996-07-16 | — | — | US | claimed |
| US-5486617-A | Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes | LONZA LTD. (CH) | 1996-01-23 | — | — | US | claimed |
| EP-0653422-A1 | Process for the preparation of 2-substituted 5-chlorimidazole-4-carbaldehydes | LONZA AG (CH) | 1995-05-17 | — | — | EP | claimed |
| EP-0743306-B1 | Process for the preparation of optionally 2-substituted 5-chloro-imidazole-4-carbaldehydes | LONZA AG (CH) | 2001-01-17 | — | — | EP | disclosed |
| EP-0653422-B1 | Process for the preparation of 2-substituted 5-chlorimidazole-4-carbaldehydes | LONZA AG (CH) | 1998-02-25 | — | — | EP | disclosed |
| US-5536841-A | Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes | LONZA LTD. (CH) | 1996-07-16 | — | — | US | disclosed |
| US-5536841-A | Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes | LONZA LTD. (CH) | 1996-07-16 | — | — | US | disclosed |
| US-5486617-A | Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes | LONZA LTD. (CH) | 1996-01-23 | — | — | US | disclosed |
| US-5486617-A | Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes | LONZA LTD. (CH) | 1996-01-23 | — | — | US | disclosed |
| EP-0653422-A1 | Process for the preparation of 2-substituted 5-chlorimidazole-4-carbaldehydes | LONZA AG (CH) | 1995-05-17 | — | — | EP | disclosed |
| EP-0653422-A1 | Process for the preparation of 2-substituted 5-chlorimidazole-4-carbaldehydes | LONZA AG (CH) | 1995-05-17 | — | — | EP | disclosed |