Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.69 |
| ▸ | PRKCA | P17252 | 2/20 | 0.69 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.69 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.69 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.69 |
| ▸ | EGFR | P00533 | 1/20 | 0.69 |
| ▸ | RAF1 | P04049 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | LCK | P06239 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | FRK | P42685 | 1/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7767969 | 1.00 | MAPK14 (0.69) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| Hydrochloric Acid SCHEMBL7767916 | 0.99 | MAPK14 (0.68) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| Hydrochloric Acid SCHEMBL7767914 | 0.99 | MAPK14 (0.68) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL7767926 | 0.87 | MAPK14 (0.90) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL7771977 | 0.86 | MAPK14 (0.73) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL7771978 | 0.86 | MAPK14 (0.73) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL7773635 | 0.84 | MAPK14 (0.84) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL7767982 | 0.84 | MAPK14 (0.84) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL8473131 | 0.83 | MAPK14 (0.65) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 | |
| SCHEMBL7771968 | 0.83 | MAPK14 (0.83) | MAPK14PRKD3MAP4K4PRKCACSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251914-B1 | TREATING CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION | 2001-06-26 | — | — | US | disclosed |
| EP-1019396-A1 | NOVEL CYCLOALKYL SUBSTITUTED IMIDAZOLES | SmithKline Beecham Corporation (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999001452-A1 | NOVEL CYCLOALKYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |