Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.55 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198467 | 0.94 | PTPN1 (0.60) | PTPN1ELANEPSEN1PSEN2APH1B | |
| SCHEMBL4598237 | 0.92 | PSEN1 (0.49) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9440383 | 0.87 | PTPN1 (0.57) | PTPN1ELANEPSEN1PSEN2APH1B | |
| SCHEMBL1045679 | 0.85 | ELANE (0.54) | PTPN1ELANEPSEN1PSEN2APH1B | |
| SCHEMBL2611828 | 0.84 | MAPT (0.47) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3203038 | 0.83 | PTPN1 (0.52) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8752337 | 0.83 | CYP1A2 (0.52) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4265630 | 0.81 | PTPN1 (0.51) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6225351 | 0.81 | PTPN1 (0.51) | PTPN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3186678 | 0.81 | PTPN1 (0.51) | PTPN1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| US-5830920-A | PREVENTION GROWTH OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |