SCHEMBL7769814

SCHEMBL7769814

CCCCC[Si@H]1CC[C@H](CCCC[C@H]2CC[C@H](c3ccc(C(F)(F)Cl)c(F)c3)CC2)CC1

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
CYP2C9 P11712 1/20 0.31
MAPT P10636 2/20 0.30
GAA P10253 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7769816 1.00 MEN1 (0.31) MEN1KMT2ACYP2C9MAPTGAA
SCHEMBL7762532 0.92 KDM1A (0.37) MEN1KMT2ACYP2C9MAPTGAA
SCHEMBL7762536 0.92 KDM1A (0.37) MEN1KMT2ACYP2C9MAPTGAA
SCHEMBL7762527 0.92 KDM1A (0.37) MEN1KMT2ACYP2C9MAPTGAA
SCHEMBL7769995 0.87 MEN1 (0.34) MEN1KMT2ACYP2C9MAPTGAA
SCHEMBL7769997 0.87 MEN1 (0.34) MEN1KMT2ACYP2C9MAPTGAA
SCHEMBL7770000 0.87 MEN1 (0.34) MEN1KMT2ACYP2C9MAPTGAA
SCHEMBL7762209 0.86 MEN1 (0.35) MEN1KMT2A
SCHEMBL7762214 0.86 MEN1 (0.35) MEN1KMT2A
SCHEMBL7766080 0.84 MAPT (0.38) MEN1KMT2ACYP2C9MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727428-B1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHINETSU CHEMICAL CO (JP) 2001-06-06 EP disclosed
US-5665271-A Silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-09-09 US disclosed
EP-0727428-A1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-08-21 EP disclosed