Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7768661 | 0.88 | CYP3A4 (0.46) | KMT2ACYP3A4 | |
| SCHEMBL7770194 | 0.88 | CYP3A4 (0.46) | HDAC1ALDH1A1GAAKCNH2HRH3 | |
| SCHEMBL7770185 | 0.87 | HDAC3 (0.37) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7770189 | 0.85 | HDAC3 (0.42) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7770738 | 0.85 | NPY5R (0.51) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7768664 | 0.80 | CYP3A4 (0.45) | MAPTKMT2ACYP3A4 | |
| SCHEMBL7768675 | 0.79 | NPY5R (0.39) | MAPTALDH1A1CYP1A2GAACYP2D6 | |
| SCHEMBL7773023 | 0.79 | NPY5R (0.42) | ALDH1A1NPY5R | |
| SCHEMBL7770742 | 0.78 | CYP3A4 (0.46) | KMT2ACYP3A4 | |
| SCHEMBL7765138 | 0.77 | CYP3A4 (0.44) | KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749974-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-06-27 | — | — | EP | claimed |
| CN-1066739-C | Phosphonic diester deriv | OTSUKA PHARMA CO LTD (JP) | 2001-06-06 | — | — | CN | claimed |
| US-5798344-A | TREATING DIABETES, HYPERLIPIDEMIA | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-08-25 | — | — | US | claimed |
| CN-1147257-A | Phosphonic diester deriv | OTSUKA PHARMA CO LTD (JP) | 1997-04-09 | — | — | CN | claimed |
| EP-0749974-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-12-27 | — | — | EP | claimed |
| EP-0749974-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-06-27 | — | — | EP | disclosed |
| CN-1066739-C | Phosphonic diester deriv | OTSUKA PHARMA CO LTD (JP) | 2001-06-06 | — | — | CN | disclosed |
| US-5798344-A | TREATING DIABETES, HYPERLIPIDEMIA | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-08-25 | — | — | US | disclosed |
| CN-1147257-A | Phosphonic diester deriv | OTSUKA PHARMA CO LTD (JP) | 1997-04-09 | — | — | CN | disclosed |
| EP-0749974-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-12-27 | — | — | EP | disclosed |