Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.83 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.83 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.83 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.83 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.83 |
| ▸ | PRKCA | P17252 | 2/20 | 0.83 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.83 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.83 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.83 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.83 |
| ▸ | EGFR | P00533 | 2/20 | 0.83 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.83 |
| ▸ | RAF1 | P04049 | 1/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.83 |
| ▸ | LCK | P06239 | 1/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.83 |
| ▸ | FRK | P42685 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771968 | 1.00 | MAPK14 (0.83) | MAPK14CSNK1DMAPK11PRKD3MAP4K4 | |
| SCHEMBL7773635 | 0.99 | MAPK14 (0.84) | MAPK14CSNK1DMAPK11PRKD3MAP4K4 | |
| SCHEMBL7767982 | 0.97 | MAPK14 (0.84) | MAPK14CSNK1DMAPK11PRKD3MAP4K4 | |
| SCHEMBL7767926 | 0.96 | MAPK14 (0.90) | MAPK14CSNK1DMAPK11PRKD3MAP4K4 | |
| SCHEMBL30290594 | 0.91 | MAPK14 (1.00) | MAPK14CSNK1DMAPK11PRKD3MAP4K4 | |
| SCHEMBL7771993 | 0.91 | MAPK14 (0.81) | MAPK14CSNK1DMAPK11PRKD3MAP4K4 | |
| SCHEMBL173596 | 0.91 | MAPK14 (1.00) | MAPK14CSNK1DMAPK11PRKD3MAP4K4 | |
| SCHEMBL7771997 | 0.91 | MAPK14 (0.81) | MAPK14CSNK1DMAPK11PRKD3MAP4K4 | |
| SCHEMBL7775707 | 0.91 | MAPK14 (0.81) | MAPK14CSNK1DMAPK11PRKD3MAP4K4 | |
| SCHEMBL173595 | 0.91 | MAPK14 (1.00) | MAPK14CSNK1DMAPK11PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495029-B2 | Prodrugs of (2R)-2-propyloctanoic acid for the treatment of stroke | MERCK & CO., INC (US) | 2009-02-24 | — | — | US | disclosed |
| US-20080132488-A1 | Prodrugs of (2R)-2-Propyloctanoic Acid For the Treatment of Stroke | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-06-05 | — | — | US | disclosed |
| US-6251914-B1 | TREATING CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION | 2001-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132488-A1 | Prodrugs of (2R)-2-Propyloctanoic Acid For the Treatment of Stroke | APEH, HCAR2, PTGDR | MAPK14 2899/4885CSNK1D 3668/4885MAPK11 1820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.