Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2338241 | 0.93 | HDAC1 (0.51) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL7776648 | 0.93 | HDAC1 (0.51) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL7776407 | 0.93 | HDAC1 (0.51) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL7776254 | 0.92 | HDAC1 (0.51) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL7776246 | 0.92 | HDAC1 (0.51) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL7775499 | 0.92 | HDAC1 (0.48) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL7781609 | 0.92 | HDAC1 (0.49) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL8444854 | 0.92 | HDAC1 (0.48) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL7779661 | 0.92 | HDAC1 (0.48) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL12300040 | 0.91 | HDAC1 (0.42) | HDAC1HDAC4HDAC3HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2277387-B1 | NEW USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY | NATUREWISE BIOTECH & MEDICALS CORP (TW) | 2016-10-19 | — | — | EP | disclosed |
| US-9427424-B2 | Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2016-08-30 | — | — | US | disclosed |
| US-20140288166-A1 | USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY | NATUREWISE BIOTECH & MEDICALS CORP (TW) | 2014-09-25 | — | — | US | disclosed |
| US-8784873-B2 | Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2014-07-22 | — | — | US | disclosed |
| US-8318801-B2 | Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2012-11-27 | — | — | US | disclosed |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-09-15 | — | — | US | disclosed |
| US-7994357-B2 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-08-09 | — | — | US | disclosed |
| US-7994357-B2 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-08-09 | — | — | US | disclosed |
| US-20110020462-A1 | NEW USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-01-27 | — | — | US | disclosed |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2010-10-07 | — | — | US | disclosed |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2010-10-07 | — | — | US | disclosed |
| EP-2236503-A1 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NatureWise Biotech & Medicals Corporation (TW) | 2010-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110020462-A1 | NEW USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY | BRPF3, BRD3, BRDT | HDAC1 5/4885HDAC4 34/4885HDAC3 4/4885 |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | SMN1; SMN2, HDAC1, HDAC5 | HDAC1 2/4885HDAC4 6/4885HDAC3 12/4885 |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | SMN1; SMN2, HDAC1, HDAC5 | HDAC1 2/4885HDAC4 6/4885HDAC3 12/4885 |
| US-20140288166-A1 | USE OF HISTONE DEACETYLASE INHIBITORS IN CHANGING MRJP3 PROTEIN IN ROYAL JELLY | BRPF3, BRD3, BRDT | HDAC1 5/4885HDAC4 35/4885HDAC3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.