Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | GAPDH | P04406 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7777307 | 0.83 | ABL1 (0.50) | BACE1SMN1; SMN2HSD17B10ALDH1A1HPGD | |
| SCHEMBL7778332 | 0.80 | ESR2 (0.57) | BACE1SMN1; SMN2HSD17B10ALDH1A1HPGD | |
| SCHEMBL30610973 | 0.80 | HDAC3 (0.51) | SMN1; SMN2HPGDKDM4ECYP1A2CYP2D6 | |
| SCHEMBL8460805 | 0.78 | BACE1 (0.57) | BACE1SMN1; SMN2HSD17B10ALDH1A1HPGD | |
| SCHEMBL2608606 | 0.77 | HSD17B10 (0.66) | BACE1SMN1; SMN2HSD17B10ALDH1A1F2 | |
| SCHEMBL14700512 | 0.77 | HSD17B10 (0.66) | BACE1SMN1; SMN2HSD17B10ALDH1A1F2 | |
| SCHEMBL6173663 | 0.77 | BACE1 (0.56) | BACE1SMN1; SMN2HSD17B10ALDH1A1F2 | |
| SCHEMBL30610959 | 0.77 | MAPT (0.47) | HSD17B10ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL27627378 | 0.77 | KDM4E (0.53) | BACE1ALDH1A1KDM4ELMNACYP3A4 | |
| SCHEMBL9912737 | 0.77 | MAPT (0.47) | HSD17B10ALDH1A1KDM4ELMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121125-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2001-08-08 | — | — | EP | claimed |
| WO-2000021535-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2000-04-20 | — | — | WO | claimed |
| EP-1121125-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000021535-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2000-04-20 | — | — | WO | disclosed |