Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.48 |
| ▸ | CDK4 | P11802 | 6/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387422 | 0.94 | EGFR (0.65) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL1387382 | 0.86 | MEN1 (0.52) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL1387593 | 0.84 | CDK2 (0.56) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7778634 | 0.81 | EGFR (0.61) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL8798594 | 0.81 | EGFR (0.85) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7777399 | 0.81 | EGFR (0.55) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7776029 | 0.81 | MEN1 (0.54) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL8318193 | 0.80 | EGFR (0.55) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7771239 | 0.80 | EGFR (0.54) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL8799214 | 0.80 | EGFR (0.83) | EGFRMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |