Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 6/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.49 |
| ▸ | HCK | P08631 | 2/20 | 0.49 |
| ▸ | BTK | Q06187 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771263 | 0.87 | EGFR (0.52) | MEN1KMT2AEGFRHDAC3HDAC4 | |
| SCHEMBL7771232 | 0.86 | MEN1 (0.70) | MEN1KMT2AEGFRAPPNPC1 | |
| SCHEMBL7778638 | 0.83 | SYK (0.51) | MEN1KMT2AEGFRHDAC3HDAC4 | |
| SCHEMBL2286784 | 0.82 | NPC1 (0.56) | MEN1KMT2AEGFRHCKBTK | |
| SCHEMBL7775667 | 0.80 | EGFR (0.60) | EGFRAPPMAPT | |
| SCHEMBL7775606 | 0.80 | SYK (0.48) | MEN1KMT2AEGFRHDAC3HDAC4 | |
| SCHEMBL1387327 | 0.79 | APP (0.62) | MEN1KMT2AEGFRAPPNPC1 | |
| SCHEMBL1387439 | 0.79 | EGFR (0.49) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1387307 | 0.79 | CDK4 (0.50) | MEN1KMT2AEGFRHDAC3HDAC4 | |
| SCHEMBL19480017 | 0.79 | KDR (0.71) | EGFRHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |