Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 0.90 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.90 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.90 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.90 |
| ▸ | PGR | P06401 | 3/20 | 0.90 |
| ▸ | TSHR | P16473 | 2/20 | 0.90 |
| ▸ | AR | P10275 | 2/20 | 0.90 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.90 |
| ▸ | MEN1 | O00255 | 1/20 | 0.90 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | APEX1 | P27695 | 1/20 | 0.90 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.90 |
| ▸ | IKBKB | O14920 | 1/20 | 0.90 |
| ▸ | CHUK | O15111 | 1/20 | 0.90 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.90 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.90 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.90 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betamethasone SCHEMBL8508844 | 1.00 | HIF1A (0.90) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL1301201 | 1.00 | HIF1A (0.90) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL6908689 | 1.00 | HIF1A (0.90) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL12099597 | 0.99 | HIF1A (0.89) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL3456100 | 0.98 | HIF1A (0.86) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL9112497 | 0.98 | HIF1A (0.86) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL13740162 | 0.98 | HIF1A (0.86) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL15415155 | 0.97 | HIF1A (0.89) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL27582183 | 0.97 | HIF1A (0.89) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL337333 | 0.97 | HIF1A (0.89) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 18009 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121490062-B | Dexamethasone-containing composition and application thereof in preparation of medicament for treating retinopathy | 上饶爱尔眼科医院有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4725558-A2 | IMMUNOABLATIVE THERAPIES | AVM Biotechnology, LLC (US) | 2026-04-15 | — | — | EP | claimed |
| EP-4719194-A1 | METHODS FOR INCORPORATING THERAPEUTIC AGENTS INTO ANALYTE SENSORS | Abbott Diabetes Care, Inc. (US) | 2026-04-08 | — | — | EP | claimed |
| EP-3820479-B1 | METHODS TO REDUCE COMPLICATIONS OF INTRA-ARTICULAR STEROID | TAIWAN LIPOSOME CO LTD (TW) | 2026-03-11 | — | — | EP | claimed |
| EP-3860612-B1 | IMMUNOABLATIVE THERAPIES | AVM BIOTECHNOLOGY LLC (US) | 2026-03-04 | — | — | EP | claimed |
| EP-4701663-A1 | PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS, COMBINATIONS AND USES THEREOF | Insilico Medicine IP Limited (HK) | 2026-03-04 | — | — | EP | claimed |
| US-12558544-B2 | Cochlear implant with multi-layer electrode | COCHLEAR LIMITED (AU) | 2026-02-24 | — | — | US | claimed |
| US-20260021113-A1 | INTRAVITREAL CORTICOSTEROID EXTENDED RELEASE IMPLANT AND METHODS OF USE | EYEDEA BIO LLC (US) | 2026-01-22 | — | — | US | claimed |
| US-12514820-B2 | Pharmaceutical composition of intra-articular corticosteroid for pain control | TAIWAN LIPOSOME CO., LTD. (TW) | 2026-01-06 | — | — | US | claimed |
| US-12491213-B2 | Technical method for treating vitiligo through hair follicle melanocyte stem cell transplantation | HAIKOU RENSHU DERMATOLOGY CLINIC CO., LTD (CN) | 2025-12-09 | — | — | US | claimed |
| WO-1990003782-A2 | FINELY DIVIDED SOLID CRYSTALLINE POWDERS VIA PRECIPITATION INTO AN ANTI-SOLVENT | THE UPJOHN COMPANY (US) | 1990-04-19 | — | — | WO | claimed |
| EP-0244178-A2 | Intraocular dosage compositions and method of use | IOLAB, INC (US) | 1987-11-04 | — | — | EP | claimed |
| EP-0060451-B1 | IONTOPHORETIC ELECTRODE | MEDTRONIC, INC. (US) | 1986-09-17 | — | — | EP | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |
| EP-0126684-A2 | Drug delivery system utilizing thermosetting gels | MERCK & CO. INC. (US) | 1984-11-28 | — | — | EP | claimed |
| US-4406883-A | SHAPES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-27 | — | — | US | claimed |
| EP-0060451-A1 | Iontophoretic electrode | MEDTRONIC, INC. (US) | 1982-09-22 | — | — | EP | claimed |
| US-4304765-A | Ocular insert housing steroid in two different therapeutic forms | ALZA CORPORATION (US) | 1981-12-08 | — | — | US | claimed |
| US-4292300-A | METHYL CELLULOSE, WATER, DRUG | INVERESK RESEARCH INTERNATIONAL (GB) | 1981-09-29 | — | — | US | claimed |
| US-4265875-A | HYDROXYPROPYL METHYL CELLULOSE | INVERESK RESEARCH INTERNATIONAL (GB) | 1981-05-05 | — | — | US | claimed |