⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7779679 | 1.00 | — | — | |
| SCHEMBL7786743 | 1.00 | — | — | |
| SCHEMBL7787693 | 1.00 | — | — | |
| SCHEMBL7779577 | 1.00 | — | — | |
| SCHEMBL7786758 | 1.00 | — | — | |
| SCHEMBL8846431 | 1.00 | — | — | |
| SCHEMBL7784089 | 0.80 | — | — | |
| SCHEMBL7786451 | 0.80 | — | — | |
| SCHEMBL7069782 | 0.78 | CDK1 (0.33) | — | |
| SCHEMBL7069780 | 0.78 | CDK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837679-B1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH INC (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6008240-A | AN ANTAGONIST OF HISTAMINE H3 RECEPTORS; FOR TREATING ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE (HYPER OR HYPOTENSION), GASTROINTESTINAL DISORDERS, CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5990317-A | HISTAMINE H3 RECEPTOR ANTAGONIST FOR TREATING CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5652258-A | HISTAMINE ANTAGONISTS | GLIATECH, INC. (US) | 1997-07-29 | — | — | US | disclosed |