Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.37 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412279 | 0.88 | PDE4B (0.41) | NPC1RAB9ACA12CA1CA2 | |
| SCHEMBL7782729 | 0.85 | HDAC3 (0.38) | NPC1RAB9ACA1CA2KDM4E | |
| SCHEMBL7537360 | 0.75 | ERN1 (0.33) | NPC1RAB9AKDM4ELMNAALDH1A1 | |
| SCHEMBL9267225 | 0.72 | KDM4E (0.46) | NPC1RAB9ACA12CA1CA2 | |
| SCHEMBL15758898 | 0.72 | KDM4E (0.46) | NPC1RAB9ACA12CA1CA2 | |
| Ethyl Cinnamate SCHEMBL112446 | 0.68 | CA12 (0.72) | NPC1RAB9ACA12CA1CA2 | |
| Ethyl Cinnamate SCHEMBL112445 | 0.68 | CA12 (0.72) | NPC1RAB9ACA12CA1CA2 | |
| Ethyl Cinnamate SCHEMBL12001792 | 0.68 | CA12 (0.72) | NPC1RAB9ACA12CA1CA2 | |
| Ethyl Cinnamate SCHEMBL1866942 | 0.68 | CA12 (0.72) | NPC1RAB9ACA12CA1CA2 | |
| SCHEMBL8481698 | 0.68 | MAPT (0.47) | NPC1RAB9ACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135377-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000034254-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-06-15 | — | — | WO | disclosed |