Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ACP3 | P15309 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780406 | 1.00 | GRM8 (0.55) | GRM8GRM4ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL27556859 | 0.93 | GRM8 (0.50) | GRM8GRM4ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL27530416 | 0.93 | GRM8 (0.50) | GRM8GRM4ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL27530331 | 0.93 | GRM8 (0.50) | GRM8GRM4ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL27530411 | 0.93 | GRM8 (0.50) | GRM8GRM4ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL27556857 | 0.93 | GRM8 (0.50) | GRM8GRM4ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL27530328 | 0.93 | GRM8 (0.50) | GRM8GRM4ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7780743 | 0.90 | KMT2A (0.52) | GRM8GRM4ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL28744359 | 0.89 | GRM8 (0.49) | GRM8GRM4ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL28744362 | 0.89 | GRM8 (0.49) | GRM8GRM4ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |