Triaziquone

Triaziquone

SCHEMBL7783197

CO.O=C1C=C(N2CC2)C(=O)C(N2CC2)=C1N1CC1

nearest known ligand 0.46

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.46
HTT P42858 2/20 0.46
TP53 P04637 1/20 0.46
STAT3 P40763 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
DNMT1 P26358 1/20 0.44
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
TSHR P16473 1/20 0.38
MAPK1 P28482 1/20 0.38
HIF1A Q16665 1/20 0.38
NSD2 O96028 4/20 0.37
TDP2 O95551 3/20 0.37
APAF1 O14727 2/20 0.37
HKDC1 Q2TB90 2/20 0.37
KMT2A Q03164 2/20 0.35
ATG4B Q9Y4P1 2/20 0.35
LMNA P02545 2/20 0.35
MEN1 O00255 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triaziquone SCHEMBL2063810 0.98 MAPT (0.44) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL5606305 0.94 HTT (0.42) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL8303 0.94 DNMT1 (0.48) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL149876 0.92 MAPT (0.46) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL7738777 0.91 DNMT1 (0.47) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL8482641 0.91 DNMT1 (0.47) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL1538515 0.91 DNMT1 (0.47) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL8993238 0.91 DNMT1 (0.47) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL6000230 0.91 DNMT1 (0.47) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL5054475 0.91 DNMT1 (0.47) MAPTHTTTP53STAT3SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1142908-A1 PROCESS FOR PRODUCING ACTIVATED PROTEIN Takeda Chemical Industries, Ltd. (JP) 2001-10-10 EP disclosed