Glycine

Glycine

SCHEMBL7783306

C=CC.C=CC.C=CC.NCC(=O)O

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D

The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLRA1 P23415 1/20 0.62
SLC6A9 P48067 1/20 0.62
OR51E2 Q9H255 1/20 0.62
GABRR1 P24046 5/20 0.39
TSHR P16473 5/20 0.37
BLM P54132 4/20 0.37
CYP2D6 P10635 3/20 0.37
KMT2A Q03164 2/20 0.37
NFKB1 P19838 2/20 0.37
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37
SLC6A3 Q01959 1/20 0.37
MEN1 O00255 1/20 0.37
CYP2C19 P33261 1/20 0.37
LMNA P02545 3/20 0.37
FFAR3 O14843 1/20 0.37
ALDH1A1 P00352 4/20 0.35
FGFR4 P22455 1/20 0.35
GABRR2 P28476 3/20 0.35
GABRR3 A8MPY1 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glycine SCHEMBL421804 1.00
Glycine SCHEMBL3102650 1.00 GLRA1 (0.62) GLRA1SLC6A9OR51E2GABRR1TSHR
Glycine SCHEMBL18205005 1.00 GLRA1 (0.62) GLRA1SLC6A9OR51E2GABRR1TSHR
Glycine SCHEMBL27489498 1.00 GLRA1 (0.62) GLRA1SLC6A9OR51E2GABRR1TSHR
Glycine SCHEMBL7797250 0.92 GLRA1 (0.53) GLRA1SLC6A9OR51E2GABRR1TSHR
Ether SCHEMBL5072098 0.85 GLRA1 (0.46) GLRA1SLC6A9OR51E2GABRR1TSHR
Glycine SCHEMBL11288633 0.84
Glycine SCHEMBL1148008 0.84
Glycine SCHEMBL4169207 0.81
Glycine SCHEMBL11049991 0.81 GLRA1 (0.62) GLRA1SLC6A9OR51E2GABRR1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3999671-A1 COMPOSITIONS AND METHODS FOR METAL PRE-TREATMENT Chemetall GmbH (DE) 2022-05-25 EP disclosed
EP-3994219-A1 A COATING COMPOSITION, ITS PREPARATION METHOD AND USE THEREOF BASF Coatings GmbH (DE) 2022-05-11 EP disclosed
EP-3911818-A2 A METHOD OF MAKING MOLDED PARTS HAVING SMOOTH SURFACE AND MOLDED PARTS MADE THEREOF Construction Research & Technology GmbH (DE) 2021-11-24 EP disclosed
WO-2021009186-A1 COMPOSITIONS AND METHODS FOR METAL PRE-TREATMENT CHEMETALL GMBH (DE) 2021-01-21 WO disclosed
WO-2021001190-A1 A COATING COMPOSITION, ITS PREPARATION METHOD AND USE THEREOF BASF COATINGS GMBH (DE) 2021-01-07 WO disclosed
EP-3684176-A1 TREATED MEDIUM FOR PLANT GROWTH THAT HAS INCREASED WATER RETENTION BASF SE (DE) 2020-07-29 EP disclosed
WO-2019057617-A1 TREATED MEDIUM FOR PLANT GROWTH THAT HAS INCREASED WATER RETENTION BASF SE (DE) 2019-03-28 WO disclosed
EP-1145209-A3 LOW RESILIENCE, LOW FREQUENCY MOLDED POLYURETHANE FOAM BAYER ANTWERPEN N.V. (BE) 2002-03-06 EP disclosed
EP-1145209-A2 LOW RESILIENCE, LOW FREQUENCY MOLDED POLYURETHANE FOAM BAYER ANTWERPEN N.V. (BE) 2001-10-17 EP disclosed
WO-2000017836-A2 LOW RESILIENCE, LOW FREQUENCY MOLDED POLYURETHANE FOAM BAYER ANWERPEN N.V. (BE) 2000-03-30 WO disclosed
WO-1997032566-A1 COSMETIC COMPOSITION INCLUDING AN AQUEOUS DISPERSION OF POLYMERIC PARTICLES, AND USE THEREOF L'OREAL (FR) 1997-09-12 WO disclosed
EP-0391993-A1 LUBRICANT COMPOSITIONS AND ADDITIVE CONCENTRATES FOR THEIR PREPARATION. LUBRIZOL GENETICS INC (US) 1990-10-17 EP disclosed
WO-1990004626-A2 LUBRICANT AND FUNCTIONAL FLUID COMPOSITIONS EXHIBITING IMPROVED DEMULSIBILITY THE LUBRIZOL CORPORATION (US) 1990-05-03 WO disclosed