Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29202770 | 0.80 | APOBEC3G (0.58) | APOBEC3GALDH1A1TDP1HSD17B10TSHR | |
| SCHEMBL4243059 | 0.80 | APOBEC3G (0.58) | APOBEC3GALDH1A1TDP1HSD17B10TSHR | |
| SCHEMBL5533428 | 0.80 | APOBEC3G (0.73) | APOBEC3GALDH1A1TDP1HSD17B10TSHR | |
| SCHEMBL121410 | 0.80 | APOBEC3G (1.00) | APOBEC3GALDH1A1TDP1HSD17B10TSHR | |
| SCHEMBL21326159 | 0.76 | APOBEC3G (0.67) | APOBEC3GALDH1A1TDP1HSD17B10TSHR | |
| SCHEMBL27945803 | 0.76 | APOBEC3G (0.54) | APOBEC3GALDH1A1TDP1HSD17B10TSHR | |
| SCHEMBL7022399 | 0.76 | APOBEC3G (0.67) | APOBEC3GALDH1A1TDP1HSD17B10HSD11B1 | |
| SCHEMBL3279839 | 0.76 | CA12 (0.63) | APOBEC3GALDH1A1TDP1TSHRSMN1; SMN2 | |
| SCHEMBL28696634 | 0.76 | APOBEC3G (0.54) | APOBEC3GALDH1A1TDP1HSD17B10TSHR | |
| SCHEMBL1768495 | 0.76 | APOBEC3G (0.54) | APOBEC3GALDH1A1TSHRSMN1; SMN2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144372-A1 | SULPHOHYDROXAMIC ACIDS AND SULPHOHYDROXAMATES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2001-10-17 | — | — | EP | claimed |
| WO-2000042002-A1 | SULPHOHYDROXAMIC ACIDS AND SULPHOHYDROXAMATES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | claimed |