SCHEMBL7784232

SCHEMBL7784232

CC(O)(Br)c1cccc(Cl)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.49
SCN5A Q14524 3/20 0.43
SCN9A Q15858 3/20 0.43
TSHR P16473 1/20 0.43
PGR P06401 1/20 0.42
MAPK1 P28482 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CHRM3 P20309 1/20 0.41
HSD11B1 P28845 1/20 0.41
KIF11 P52732 3/20 0.40
ALDH1A1 P00352 2/20 0.38
KCNH2 Q12809 3/20 0.38
CCR6 P51684 3/20 0.38
CYP2C19 P33261 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4294497 0.84 CYP19A1 (0.50) CYP19A1SCN5ASCN9ATSHRPGR
SCHEMBL1155523 0.84 CYP19A1 (0.50) CYP19A1SCN5ASCN9ATSHRPGR
SCHEMBL8633370 0.82 CYP19A1 (0.43) CYP19A1SCN5ASCN9ATSHRPGR
SCHEMBL29091905 0.81 CYP19A1 (0.47) CYP19A1SCN5ASCN9ATSHRPGR
SCHEMBL29092711 0.81 CYP19A1 (0.47) CYP19A1SCN5ASCN9ATSHRPGR
SCHEMBL6074031 0.81 CYP19A1 (0.47) CYP19A1SCN5ASCN9ATSHRPGR
SCHEMBL29091896 0.81 CYP19A1 (0.47) CYP19A1SCN5ASCN9ATSHRPGR
Metaglycodol SCHEMBL2108213 0.81 CYP19A1 (0.47) CYP19A1SCN5ASCN9ATSHRPGR
Methyl Alcohol SCHEMBL27512784 0.80 HDAC4 (0.48) CYP19A1SCN5ASCN9ATSHRPGR
SCHEMBL11300726 0.79 CYP19A1 (0.53) CYP19A1SCN5ASCN9ATSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4218384-A None JP disclosed
EP-0735142-B1 Process for producing (R)-styrene oxides SUMIKA FINE CHEMICALS CO LTD (JP) 2001-10-24 EP disclosed
US-5717116-A TREATING A MIXTURE OF PHENYLHALOGENOMETHYLCARBINOLS WITH A LIPASE IN THE PRESENCE OF A CARBOXYLATE FOLLOWED BY CYCLIZATION WITH A BASE SUMIKA FINE CHEMICALS COMPANY, LIMITED (JP) 1998-02-10 US disclosed
EP-0735142-A2 Process for producing (R)-styrene oxides SUMIKA FINE CHEMICAL COMPANY, LTD. (JP) 1996-10-02 EP disclosed
JP-H04218384-A PRODUCTION OF OPTICALLY ACTIVE (-)-2-HALO-1-(SUBSTITUTED PHENYL)ETHANOL AND (-)-SUBSTITUTED STYRENE OXIDE KANEGAFUCHI CHEM IND CO LTD 1992-08-07 JP disclosed