Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.78 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.78 |
| ▸ | MMP2 | P08253 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7790424 | 0.88 | TOP2A (1.00) | TOP2ATOP2BMMP2MEN1KMT2A | |
| SCHEMBL7794495 | 0.88 | TOP2A (1.00) | TOP2ATOP2BMMP2MEN1KMT2A | |
| SCHEMBL7793174 | 0.88 | TOP2A (1.00) | TOP2ATOP2BMMP2MEN1KMT2A | |
| SCHEMBL7793975 | 0.88 | TOP2A (1.00) | TOP2ATOP2BMMP2MEN1KMT2A | |
| SCHEMBL7784472 | 0.86 | TOP2A (0.63) | TOP2ATOP2BMMP2PTPN1MAPT | |
| SCHEMBL7784522 | 0.84 | TOP2A (0.85) | TOP2ATOP2BMEN1KMT2APTPN1 | |
| SCHEMBL7789968 | 0.82 | TOP2A (0.85) | TOP2ATOP2BMEN1KMT2APTPN1 | |
| SCHEMBL7793657 | 0.82 | TOP2A (0.85) | TOP2ATOP2BMEN1KMT2APTPN1 | |
| SCHEMBL7790412 | 0.80 | TOP2A (0.75) | TOP2ATOP2BMEN1KMT2AMAPT | |
| SCHEMBL7790409 | 0.80 | TOP2A (0.81) | TOP2ATOP2BPTPN1EPHX2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156056-A1 | 5-GLYCOSYLOXY-6-HYDROXYNAPHTHO 2,3-f]QUINOLINE-7,12-DIONE HAVING ANTICANCER ACTIVITIES | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 2001-11-21 | — | — | EP | claimed |
| EP-1156056-A1 | 5-GLYCOSYLOXY-6-HYDROXYNAPHTHO 2,3-f]QUINOLINE-7,12-DIONE HAVING ANTICANCER ACTIVITIES | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 2001-11-21 | — | — | EP | disclosed |