Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K2 | P36507 | 7/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.46 |
| ▸ | BCL3 | P20749 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854395 | 0.90 | TSHR (0.46) | MAP2K2MAP2K1BCL3KMT2AALDH1A1 | |
| SCHEMBL7787380 | 0.84 | MAP2K1 (0.45) | MAP2K2MAP2K1KMT2AMEN1TDP1 | |
| SCHEMBL7941495 | 0.83 | MAP2K1 (0.47) | MAP2K2MAP2K1KMT2AMEN1TDP1 | |
| SCHEMBL6035427 | 0.83 | MEN1 (0.48) | MAP2K2MAP2K1BCL3KMT2AALDH1A1 | |
| SCHEMBL6035215 | 0.82 | MAP2K2 (0.56) | MAP2K2MAP2K1BCL3KMT2AALDH1A1 | |
| SCHEMBL6035287 | 0.80 | BCL3 (0.59) | BCL3KMT2ALMNAJAK1TYK2 | |
| SCHEMBL6035714 | 0.80 | MEN1 (0.47) | MAP2K2MAP2K1KMT2AALDH1A1MEN1 | |
| SCHEMBL7800494 | 0.79 | MAP2K1 (0.50) | MAP2K2MAP2K1KMT2AALDH1A1 | |
| SCHEMBL6035363 | 0.78 | MAP2K1 (0.64) | MAP2K2MAP2K1KMT2AMEN1TDP1 | |
| SCHEMBL7804383 | 0.78 | KMT2A (0.46) | MAP2K2MAP2K1BCL3KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140062-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140067-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140291-A1 | COMBINATION CHEMOTHERAPY COMPRISING A MITOTIC INHIBITOR AND A MEK INHIBITOR | WARNER-LAMBERT COMPANY LLC (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037141-A9 | COMBINATION CHEMOTHERAPY | WARNER LAMBERT CO (US) | 2000-12-07 | — | — | WO | disclosed |
| WO-2000040237-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000037141-A1 | COMBINATION CHEMOTHERAPY | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |