Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexane SCHEMBL8457635 | 0.96 | TSHR (0.47) | TSHRTHRBSPHK1SMN1; SMN2LMNA | |
| Hexane SCHEMBL7784664 | 0.96 | TSHR (0.47) | TSHRTHRBSPHK1SMN1; SMN2LMNA | |
| Hexane SCHEMBL9301737 | 0.96 | TSHR (0.54) | TSHRTHRBSPHK1SMN1; SMN2LMNA | |
| Hexane SCHEMBL2244744 | 0.96 | TSHR (0.54) | TSHRTHRBSPHK1SMN1; SMN2LMNA | |
| Hexane SCHEMBL9253671 | 0.96 | TSHR (0.54) | TSHRTHRBSPHK1SMN1; SMN2LMNA | |
| Hexane SCHEMBL23068705 | 0.96 | TSHR (0.54) | TSHRTHRBSPHK1SMN1; SMN2LMNA | |
| Hexane SCHEMBL9405694 | 0.96 | TSHR (0.54) | TSHRTHRBSPHK1SMN1; SMN2LMNA | |
| Hexane SCHEMBL42593 | 0.96 | TSHR (0.54) | TSHRTHRBSPHK1SMN1; SMN2LMNA | |
| Hexane SCHEMBL9260176 | 0.96 | TSHR (0.54) | TSHRTHRBSPHK1SMN1; SMN2LMNA | |
| Hexane SCHEMBL2466815 | 0.96 | TSHR (0.54) | TSHRTHRBSPHK1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252060-B1 | COMPLEX CONTAINING DIDEOXYGUANOSINE | NEXSTAR PHARMACEUTICALS, INC. | 2001-06-26 | — | — | US | disclosed |
| US-5817638-A | USING HYBRID NUCLEOSIDES | NEXSTAR PHARMACEUTICALS, INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5780617-A | PHOSPHORYLATION OF A PHOSPHATIDES WITH A NUCLEOTIDES | NEXSTAR PHARMACEUTICALS, INC. (US) | 1998-07-14 | — | — | US | disclosed |
| EP-0594677-A4 | ANTIVIRAL LIPONUCLEOSIDES: TREATMENT OF HEPATITIS B | VICAL INC (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0594677-A1 | ANTIVIRAL LIPONUCLEOSIDES: TREATMENT OF HEPATITIS B | NeXstar Pharmaceuticals, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0531452-A4 | SYNTHESIS OF GLYCEROL DI- AND TRIPHOSPHATE DERIVATIVES | — | 1993-06-09 | — | — | EP | disclosed |
| EP-0531452-A1 | SYNTHESIS OF GLYCEROL DI- AND TRIPHOSPHATE DERIVATIVES | NeXstar Pharmaceuticals, Inc. (US) | 1993-03-17 | — | — | EP | disclosed |
| WO-1993000910-A1 | ANTIVIRAL LIPONUCLEOSIDES: TREATMENT OF HEPATITIS B | VICAL, INC. (US) | 1993-01-21 | — | — | WO | disclosed |
| WO-1991018914-A1 | SYNTHESIS OF GLYCEROL DI- AND TRIPHOSPHATE DERIVATIVES | VICAL, INC. (US) | 1991-12-12 | — | — | WO | disclosed |