SCHEMBL7785244

SCHEMBL7785244

N=C(N)NCCC[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O

nearest known ligand 0.58

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NPY4R P50391 15/20 0.56
NPY1R P25929 9/20 0.56
NPY5R Q15761 7/20 0.56
NPY2R P49146 5/20 0.56
KISS1R Q969F8 1/20 0.52
CTSL P07711 1/20 0.49
CTSC P53634 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14509067 0.94 NPY4R (0.56) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL3356931 0.94 NPY4R (0.64) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL14509088 0.94 NPY4R (0.56) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL3356923 0.94 NPY4R (0.64) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL13563450 0.94 NPY4R (0.64) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL22098763 0.94 NPY4R (0.56) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL5966602 0.93 GNPAT (0.52) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL1711691 0.93 GNPAT (0.52) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL1711701 0.93 GNPAT (0.52) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL29540393 0.93 GNPAT (0.52) NPY4RNPY1RNPY5RNPY2RKISS1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119060201-A Chemoenzymatic synthesis of liraglutide, soxhlet Ma Lutai and GLP-1 费森尤斯卡比有限公司 2024-12-03 CN disclosed
CN-111819191-B Chemoenzymatic synthesis of liraglutide, soxhlet Ma Lutai and GLP-1 费森尤斯卡比有限公司 2024-08-20 CN disclosed
EP-3704143-B1 CHEMO-ENZYMATIC SYNTHESIS OF LIRAGLUTIDE, SEMAGLUTIDE AND GLP-1 FRESENIUS KABI IPSUM S R L (IT) 2023-10-18 EP disclosed
EP-1140985-A1 SUBSTITUTED HETEROCYCLIC ACYL-TRIPEPTIDES USEFUL AS THROMBIN RECEPTOR MODULATORS Ortho-McNeil Pharmaceutical, Inc. (US) 2001-10-10 EP disclosed
WO-2000035942-A1 SUBSTITUTED HETEROCYCLIC ACYL-TRIPEPTIDES USEFUL AS THROMBIN RECEPTOR MODULATORS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2000-06-22 WO disclosed