Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 12/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
| ▸ | NEK4 | P51957 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7780496 | 0.99 | MAPKAPK2 (0.44) | MAPKAPK2MAPK14TEAD4MTORNPC1 | |
| SCHEMBL7785092 | 0.93 | MAPKAPK2 (0.45) | MAPKAPK2MAPK14AURKBROCK1PDGFRA | |
| SCHEMBL7789354 | 0.93 | MAPKAPK2 (0.45) | MAPKAPK2MAPK14AURKBROCK1PDGFRA | |
| SCHEMBL7785305 | 0.93 | MAPKAPK2 (0.42) | MAPKAPK2MAPK14TEAD4MTORPTGER4 | |
| SCHEMBL7805555 | 0.93 | MAPKAPK2 (0.38) | MAPKAPK2MAPK14TEAD4 | |
| SCHEMBL7785267 | 0.93 | MAPKAPK2 (0.38) | MAPKAPK2MAPK14TEAD4 | |
| SCHEMBL7785614 | 0.93 | MAPKAPK2 (0.42) | MAPKAPK2MAPK14TEAD4MTORPTGER4 | |
| Hydrochloric Acid SCHEMBL7780386 | 0.92 | MAPKAPK2 (0.41) | MAPKAPK2MAPK14TEAD4MTORPTGER4 | |
| Hydrochloric Acid SCHEMBL7795475 | 0.92 | MAPKAPK2 (0.38) | MAPKAPK2MAPK14TEAD4 | |
| SCHEMBL7787894 | 0.91 | MAPKAPK2 (0.47) | MAPKAPK2MAPK14TEAD4MTORAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | claimed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | claimed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |