Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 7/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.46 |
| ▸ | PRKCA | P17252 | 4/20 | 0.40 |
| ▸ | PIM1 | P11309 | 6/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL800479 | 0.94 | PRKCQ (0.51) | PRKCQPRKCDPRKCAPIM1PRKCG | |
| SCHEMBL799916 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDPRKCAPIM1PRKCG | |
| SCHEMBL800201 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDPRKCAPIM1PRKCG | |
| SCHEMBL799872 | 0.84 | PRKCQ (0.49) | PRKCQPRKCDPRKCAPIM1PRKCG | |
| SCHEMBL12347381 | 0.82 | PRKCQ (0.54) | PRKCQPRKCDPRKCAPRKCGPRKCB | |
| SCHEMBL14718095 | 0.82 | PRKCQ (0.54) | PRKCQPRKCDPRKCAPRKCGPRKCB | |
| SCHEMBL799880 | 0.80 | PRKCQ (0.71) | PRKCQPRKCDPRKCAPRKCGPRKCB | |
| SCHEMBL800300 | 0.80 | PRKCQ (0.71) | PRKCQPRKCDPRKCAPRKCGPRKCB | |
| SCHEMBL780613 | 0.80 | PRKCQ (0.39) | PRKCQPRKCDPRKCAPRKCGPRKCB | |
| SCHEMBL9882221 | 0.76 | PRKCQ (0.44) | PRKCQPRKCDPRKCAPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528917-B1 | PYRAZOLOPYRIDINES USEFUL FOR THE TREATMENT OF AUTOIMMUNE, INFLAMMATORY OR (HYPER)PROLIFERATIVE DISEASES | VERTEX PHARMA (US) | 2016-10-19 | — | — | EP | disclosed |
| EP-2528917-B1 | PYRAZOLOPYRIDINES USEFUL FOR THE TREATMENT OF AUTOIMMUNE, INFLAMMATORY OR (HYPER)PROLIFERATIVE DISEASES | VERTEX PHARMA (US) | 2016-10-19 | — | — | EP | disclosed |
| US-9067932-B2 | Pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-06-30 | — | — | US | disclosed |
| US-9067932-B2 | Pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-06-30 | — | — | US | disclosed |
| US-20120071494-A1 | PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071494-A1 | PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071494-A1 | PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071494-A1 | PYRAZOLOPYRIDINE KINASE INHIBITORS | MAP3K5, MAP3K20, MAP3K1 | PRKCQ 41/4885PRKCD 111/4885PRKCA 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.