Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 18/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787761 | 1.00 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DSLC6A4 | |
| SCHEMBL8569760 | 1.00 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DSLC6A4 | |
| SCHEMBL8057577 | 0.91 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7178035 | 0.91 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8041955 | 0.91 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8651739 | 0.89 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8649228 | 0.89 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8651892 | 0.89 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8651741 | 0.89 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8651894 | 0.89 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722322-B1 | COMPOUNDS, COMPOSITIONS AND TREATMENT OF ALLERGIES AND INFLAMMATION THEREWITH | SMITHKLINE BEECHAM CORP (US) | 2001-11-14 | — | — | EP | claimed |
| US-5780667-A | Compounds, compositions and treatment of allergies and inflammation therewith | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-14 | — | — | US | claimed |
| EP-0722322-B1 | COMPOUNDS, COMPOSITIONS AND TREATMENT OF ALLERGIES AND INFLAMMATION THEREWITH | SMITHKLINE BEECHAM CORP (US) | 2001-11-14 | — | — | EP | disclosed |
| US-5780667-A | Compounds, compositions and treatment of allergies and inflammation therewith | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |