Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.49 |
| ▸ | CCND1 | P24385 | 13/20 | 0.49 |
| ▸ | CCND2 | P30279 | 13/20 | 0.49 |
| ▸ | CCND3 | P30281 | 13/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795377 | 0.84 | CDK4 (0.50) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL7788353 | 0.83 | NPC1 (0.41) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL6808164 | 0.80 | CDK4 (0.58) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL7506191 | 0.79 | CDK4 (0.54) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL23413922 | 0.76 | PIM1 (0.51) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6812598 | 0.75 | CDK4 (0.56) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6808956 | 0.72 | CDK4 (0.60) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL7504710 | 0.71 | CDK4 (0.56) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL24668741 | 0.71 | CDK4 (0.46) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL24668732 | 0.71 | CDK4 (0.42) | CDK4CCND1CCND2CCND3CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404695-B2 | Pyrimidinyl pyridone inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404695-B2 | Pyrimidinyl pyridone inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2013-03-26 | — | — | US | disclosed |
| WO-2010046273-A2 | PYRIMIDINYL PYRIDONE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2010-04-29 | — | — | WO | disclosed |
| US-20100099691-A1 | PYRIMIDINYL PYRIDONE INHIBITORS OF JNK | ROCHE PALO ALTO LLC | 2010-04-22 | — | — | US | disclosed |
| US-20100099691-A1 | PYRIMIDINYL PYRIDONE INHIBITORS OF JNK | ROCHE PALO ALTO LLC | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099691-A1 | PYRIMIDINYL PYRIDONE INHIBITORS OF JNK | MAP3K20, MAP3K6, MAP3K1 | CDK4 168/4885CCND1 506/4885CCND2 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.