Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.62 |
| ▸ | BRAF | P15056 | 3/20 | 0.62 |
| ▸ | TOP2A | P11388 | 1/20 | 0.55 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578900 | 0.84 | MAPK1 (0.51) | TNNI3KBRAF | |
| SCHEMBL3004037 | 0.83 | NPC1 (0.69) | TNNI3KBRAF | |
| SCHEMBL2995191 | 0.81 | BRAF (0.75) | TNNI3KBRAF | |
| SCHEMBL3001570 | 0.81 | BRAF (0.77) | TNNI3KBRAF | |
| SCHEMBL2995235 | 0.79 | BRAF (0.73) | TNNI3KBRAF | |
| SCHEMBL3001381 | 0.78 | TNNI3K (0.61) | TNNI3KBRAF | |
| SCHEMBL12491980 | 0.78 | MAPK1 (0.56) | — | |
| SCHEMBL12518610 | 0.77 | MAPK1 (0.58) | — | |
| SCHEMBL15121705 | 0.76 | BRAF (0.60) | TNNI3KBRAF | |
| SCHEMBL12519774 | 0.76 | MAPK1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153024-A1 | 2-AMINO-6-ANILINO-PURINES AND THEIR USE AS MEDICAMENTS | Novartis AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000049018-A1 | 2-AMINO-6-ANILINO-PURINES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2000-08-24 | — | — | WO | disclosed |