Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 17/20 | 0.81 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 2/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572803 | 0.90 | PTPN1 (0.92) | PTPN1KLKB1 | |
| SCHEMBL7673798 | 0.89 | PTPN1 (1.00) | PTPN1KLKB1PTPN22 | |
| SCHEMBL6571540 | 0.89 | PTPN1 (0.84) | PTPN1 | |
| SCHEMBL4317420 | 0.88 | PTPN1 (1.00) | PTPN1 | |
| SCHEMBL4317427 | 0.88 | PTPN1 (1.00) | PTPN1 | |
| SCHEMBL6571416 | 0.87 | PTPN1 (0.87) | PTPN1 | |
| SCHEMBL6572617 | 0.87 | PTPN1 (0.87) | PTPN1KLKB1 | |
| SCHEMBL6574724 | 0.87 | PTPN1 (1.00) | PTPN1 | |
| SCHEMBL6571565 | 0.86 | PTPN1 (1.00) | PTPN1KLKB1 | |
| SCHEMBL6572512 | 0.86 | PTPN1 (0.88) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161421-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | Pharmacia & Upjohn Aktiebolag (SE) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000053583-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2000-09-14 | — | — | WO | disclosed |