Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terpyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | CCR1 | P32246 | 3/20 | 0.53 |
| ▸ | CCR5 | P51681 | 3/20 | 0.53 |
| ▸ | CCR8 | P51685 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | ALPG | P10696 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Mercaptopyridine SCHEMBL7785225 | 0.89 | CCR1 (0.47) | KDM4ELMNACCR1CCR5CCR8 | |
| Terpyridine SCHEMBL7793859 | 0.82 | KDM4E (0.72) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL31707325 | 0.80 | KDM4E (0.64) | KDM4ELMNACCR1CCR5CCR8 | |
| Terpyridine SCHEMBL30883364 | 0.78 | KDM4E (0.55) | KDM4ELMNACCR1CCR5CCR8 | |
| 4-Mercaptopyridine SCHEMBL7790757 | 0.77 | CCR1 (0.55) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL29085081 | 0.75 | KDM4E (0.67) | KDM4ELMNACCR1CCR5CCR8 | |
| Terpyridine SCHEMBL29941316 | 0.75 | KDM4E (0.95) | KDM4ELMNACCR1CCR5CCR8 | |
| Terpyridine SCHEMBL2406854 | 0.73 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Terpyridine SCHEMBL5396565 | 0.73 | KDM4E (0.90) | KDM4ELMNACCR1CCR5CCR8 | |
| Terpyridine SCHEMBL30610403 | 0.73 | KDM4E (0.90) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155025-A1 | PLATINUM (II) COMPOUNDS | ISIS INNOVATION LIMITED (GB) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050431-A1 | PLATINUM (II) COMPOUNDS | ISIS INNOVATION LIMITED (GB) | 2000-08-31 | — | — | WO | disclosed |