Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | TCF4 | P15884 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794951 | 0.96 | CHRNB4 (0.47) | CHRNB4CHRNA3MEN1KMT2ACHEK1 | |
| SCHEMBL7786162 | 0.94 | CHRNB4 (0.48) | CHRNB4CHRNA3MEN1KMT2ACHEK1 | |
| SCHEMBL7792203 | 0.92 | CHRNB4 (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4KCNA3 | |
| SCHEMBL7794880 | 0.91 | CHRNB4 (0.44) | CHRNB4CHRNA3MEN1KMT2ACHEK1 | |
| SCHEMBL7795907 | 0.91 | CHRNB4 (0.42) | CHRNB4CHRNA3CHRNB2CHRNA4KCNA3 | |
| SCHEMBL7794691 | 0.90 | CHRNB4 (0.45) | CHRNB4CHRNA3MEN1KMT2ACHEK1 | |
| SCHEMBL7795755 | 0.90 | CHRNB4 (0.45) | CHRNB4CHRNA3MEN1KMT2ACHEK1 | |
| SCHEMBL7792117 | 0.90 | CHRNB4 (0.44) | CHRNB4CHRNA3MEN1KMT2ACHEK1 | |
| SCHEMBL7795723 | 0.89 | ELANE (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4KCNA3 | |
| SCHEMBL7792650 | 0.88 | PIM1 (0.42) | CHRNB4CHRNA3KMT2ACHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |