⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31324750 | 0.80 | — | — | |
| SCHEMBL20931243 | 0.77 | SMN1; SMN2 (0.43) | — | |
| SCHEMBL31324711 | 0.76 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL31324723 | 0.76 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL7276278 | 0.76 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL222114 | 0.74 | — | — | |
| SCHEMBL9457204 | 0.74 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL31324730 | 0.72 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL31648857 | 0.72 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL31324777 | 0.72 | SMN1; SMN2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104511026-A | Modification adenosine receptor agonist nanoprobe, and production method and use thereof | UNIV FUDAN | 2015-04-15 | — | — | CN | claimed |
| EP-4285906-A2 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF | Epizyme Inc (US) | 2023-12-06 | — | — | EP | disclosed |
| EP-3555070-B1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF | EPIZYME INC (US) | 2023-08-09 | — | — | EP | disclosed |
| CN-116041346-A | Amine-substituted heterocyclic compounds as EHMT2 inhibitors and methods of use thereof | EPIZYME股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-110088099-B | Amine-substituted heterocyclic compounds as EHMT2 inhibitors and methods of use thereof | EPIZYME股份有限公司 | 2023-01-31 | — | — | CN | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-20220235065-A1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF | Epizyme, Inc. | 2022-07-28 | — | — | US | disclosed |
| US-20200039998-A1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF | Epizyme, Inc. | 2020-02-06 | — | — | US | disclosed |
| EP-3555070-A1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF | Epizyme Inc (US) | 2019-10-23 | — | — | EP | disclosed |
| CN-104511026-B | Modify adenosine receptor agonist nano-probe and its preparation method and application | 复旦大学 | 2018-07-24 | — | — | CN | disclosed |
| EP-2822559-A1 | IMIDAZO [1, 2 - B]PYRIDAZINE - BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | Lexicon Pharmaceuticals, Inc. (US) | 2015-01-14 | — | — | EP | disclosed |
| US-20130245021-A1 | IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2013-09-19 | — | — | US | disclosed |
| WO-2013134219-A1 | IMIDAZO [1, 2 - B] PYRIDAZINE - BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS, INC. (US) | 2013-09-12 | — | — | WO | disclosed |
| US-20070185178-A1 | Triazole compounds and their use as metabotropic glutamate receptor antagonists | AATRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
| EP-0679939-B1 | Acyl substituted oxonol dyes | EASTMAN KODAK CO (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-0572635-B1 | COMPOUNDS HAVING A GUANIDINE STRUCTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | CENTRE NAT RECH SCIENT (FR) | 1996-12-27 | — | — | EP | disclosed |
| EP-0679939-A1 | Acyl substituted oxonol dyes | EASTMAN KODAK COMPANY (US) | 1995-11-02 | — | — | EP | disclosed |
| US-5451494-A | Photographic elements containing acyl substituted oxonol dyes | EASTMAN KODAK COMPANY (US) | 1995-09-19 | — | — | US | disclosed |
| US-5015554-A | Comprising an acid-forming photosensitive compound, an acid-cleavable diacetal and a water insoluble binder; photoresists; plasticizing; flexible films | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-05-14 | — | — | US | disclosed |
| EP-0302359-A2 | Positive photo-sensitive compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-08 | — | — | EP | disclosed |