Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 3/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | MC5R | P33032 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ornithine SCHEMBL7792563 | 1.00 | GRIK1 (0.44) | GRIK1GRIK2GSRMC4RMC5R | |
| Ornithine SCHEMBL7798279 | 0.99 | GRIK1 (0.43) | GRIK1GRIK2GSRMC4RMC5R | |
| Ornithine SCHEMBL7792407 | 0.96 | GRIK1 (0.41) | GRIK1GRIK2GSRMC4RMC5R | |
| Ornithine SCHEMBL7801425 | 0.96 | GRIK1 (0.41) | GRIK1GRIK2GSRMC4RMC5R | |
| Lysine SCHEMBL7800170 | 0.96 | GSR (0.48) | GRIK1GRIK2GSRMC4RMC5R | |
| Lysine SCHEMBL7800079 | 0.96 | GSR (0.48) | GRIK1GRIK2GSRMC4RMC5R | |
| Lysine SCHEMBL7798963 | 0.96 | GSR (0.48) | GRIK1GRIK2GSRMC4RMC5R | |
| Ornithine SCHEMBL7798070 | 0.95 | GRIK1 (0.41) | GRIK1GRIK2GSRMC4RMC5R | |
| Ornithine Aketoglutarate SCHEMBL7798068 | 0.95 | GRIK1 (0.41) | GRIK1GRIK2GSRMC4RMC5R | |
| Lysine SCHEMBL7801506 | 0.95 | GSR (0.47) | GRIK1GRIK2GSRMC4RMC5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |