Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920950 | 0.92 | PDE4B (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7417063 | 0.90 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7796186 | 0.90 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7796189 | 0.90 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7795024 | 0.90 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7415834 | 0.88 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6546049 | 0.86 | PDE4B (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6546052 | 0.86 | PDE4B (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6546406 | 0.86 | PDE4B (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7786638 | 0.86 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636026-B1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORP (US) | 2001-12-05 | — | — | EP | disclosed |
| US-5605923-A | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |