Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.65 |
| ▸ | PDE4A | P27815 | 4/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.65 |
| ▸ | MET | P08581 | 3/20 | 0.65 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL145002 | 0.96 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7801940 | 0.93 | PDE4B (0.62) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7802025 | 0.91 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL141309 | 0.91 | PDE4A (0.56) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7798776 | 0.90 | PDE4B (0.79) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7802000 | 0.90 | PDE4B (0.58) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL6842414 | 0.89 | PDE4B (0.77) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7800567 | 0.89 | PDE4B (0.58) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL6655462 | 0.89 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7798645 | 0.89 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4CMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723962-B1 | Arylalkyl-thiadiazinones | MERCK PATENT GMBH (DE) | 2001-07-04 | — | — | EP | disclosed |
| US-6025354-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-15 | — | — | US | disclosed |
| US-5747489-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0723962-A1 | Arylalkyl-thiadiazinones | MERCK PATENT GmbH (DE) | 1996-07-31 | — | — | EP | disclosed |