Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 7/20 | 0.44 |
| ▸ | RARG | P13631 | 7/20 | 0.44 |
| ▸ | RARA | P10276 | 5/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 4/20 | 0.38 |
| ▸ | RXRG | P48443 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794083 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1CYP26A1CYP3A4CYP26B1 | |
| SCHEMBL7794214 | 0.89 | CYP3A4 (0.45) | KDM4EALDH1A1CYP26A1CYP3A4CYP26B1 | |
| SCHEMBL8094171 | 0.89 | CYP3A4 (0.45) | KDM4EALDH1A1CYP26A1CYP3A4CYP26B1 | |
| SCHEMBL7799680 | 0.89 | CYP26A1 (0.60) | KDM4ECYP26A1CYP3A4CYP26B1RARB | |
| SCHEMBL7794061 | 0.89 | CYP26A1 (0.60) | KDM4ECYP26A1CYP3A4CYP26B1RARB | |
| SCHEMBL7801866 | 0.82 | CYP3A4 (0.45) | KDM4EALDH1A1CYP26A1CYP3A4CYP26B1 | |
| SCHEMBL7800152 | 0.82 | CYP3A4 (0.45) | KDM4EALDH1A1CYP26A1CYP3A4CYP26B1 | |
| SCHEMBL6740646 | 0.81 | CYP26A1 (0.41) | KDM4EALDH1A1CYP26A1CYP3A4CYP26B1 | |
| SCHEMBL7801697 | 0.81 | CYP26A1 (0.61) | KDM4ECYP26A1CYP3A4CYP26B1RARB | |
| SCHEMBL7801694 | 0.81 | CYP26A1 (0.61) | KDM4ECYP26A1CYP3A4CYP26B1RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882033-B1 | BENZOFURAN-ACRYLIC ACID DERIVATIVES AND THEIR USE AS MODULATORS OF RXRS OR RARS RECEPTORS | CT INTERNAT DE RECH S (FR) | 2001-08-16 | — | — | EP | claimed |
| US-6030952-A | AS HUMAN AND VETERINARY MEDICINE, PARTICULARLY IN THE TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHTHALMOLOGIC CONDITIONS, AND IN COSMETIC COMPOSITIONS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIOUES GALDERMA (FR) | 2000-02-29 | — | — | US | disclosed |