Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 5/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7796825 | 0.92 | HDAC6 (0.74) | HDAC6HDAC8HDAC3HDAC1KDM1A | |
| SCHEMBL1174737 | 0.85 | HDAC6 (1.00) | HDAC6HDAC8HDAC3HDAC1KDM1A | |
| SCHEMBL1173968 | 0.76 | HDAC6 (1.00) | HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL7864579 | 0.75 | HDAC6 (0.59) | HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL7866705 | 0.75 | HDAC6 (0.46) | HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL1174506 | 0.74 | HDAC6 (0.61) | HDAC6KDM1APRMT5WDR77 | |
| SCHEMBL1173979 | 0.73 | HDAC6 (0.66) | HDAC6HDAC8HDAC3HDAC1KDM1A | |
| SCHEMBL1174084 | 0.73 | HDAC6 (0.40) | HDAC6HDAC8 | |
| SCHEMBL1173763 | 0.73 | HDAC6 (1.00) | HDAC6HDAC1KDM1A | |
| SCHEMBL7866459 | 0.73 | HDAC6 (0.51) | HDAC6HDAC8HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140329836-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140329836-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20110046157-A1 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046157-A1 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-02-24 | — | — | US | disclosed |
| WO-2010151317-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329836-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC5, HDAC1 | HDAC6 1/4885HDAC8 11/4885HDAC3 4/4885 |
| US-20110046157-A1 | Substituted hydroxamic acids and uses thereof | HDAC6, HDAC5, HDAC1 | HDAC6 1/4885HDAC8 11/4885HDAC3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.