Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 5/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795753 | 0.99 | POLB (0.53) | POLBHTR2CPTPN1RAD52 | |
| SCHEMBL27513182 | 0.97 | HRH3 (0.52) | POLBHTR2CPTPN1KCNH2HRH3 | |
| SCHEMBL27493228 | 0.96 | HRH3 (0.50) | POLBHTR2CPTPN1RAD52KCNH2 | |
| SCHEMBL7792055 | 0.96 | POLB (0.52) | POLBHTR2CHTR2AHTR2BKCNH2 | |
| SCHEMBL7786095 | 0.95 | HRH3 (0.54) | POLBPTPN1RAD52KCNH2HRH3 | |
| SCHEMBL7794688 | 0.94 | POLB (0.53) | POLBHTR2CKCNH2HRH3 | |
| SCHEMBL7795941 | 0.94 | POLB (0.47) | POLBHTR2CPTPN1RAD52 | |
| SCHEMBL7795877 | 0.94 | POLB (0.47) | POLBHTR2CPTPN1RAD52HRH3 | |
| SCHEMBL7796613 | 0.94 | HRH3 (0.52) | PTPN1RAD52KCNH2HRH3 | |
| SCHEMBL7792338 | 0.93 | POLB (0.49) | POLBHTR2CHTR2AHTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |